Retinopathy of Prematurity
Retinopathy of prematurity (ROP) is an eye disease that affects prematurely-born babies. Both oxygen toxicity and relative hypoxia can contribute to the development of ROP. It is thought to be caused by disorganized growth of retinal blood vessels which may result in scarring and retinal detachment. ROP can be mild and may resolve spontaneously, but it may lead to blindness in serious cases. As such, all preterm babies are at risk for ROP, and very low birth weight is an additional risk factor. However, in preterm infants, the retina is often not fully vascularized. ROP occurs when the development of the retinal vasculature is arrested and then proceeds abnormally.
Patients with ROP are at greater risk for strabismus, glaucoma, cataracts and myopia later in life and should be examined yearly to help prevent and treat these conditions.
Retinal examination with pupillary dilatation and scleral depression is generally recommended for patients born before 30–32 weeks gestation, with birth weight 1500 grams or less by the treating neonatologist. The initial examination is usually performed at 4–6 weeks of life, and then repeated every 1–3 weeks until vascularization is complete (or until disease progression mandates treatment).